The Use of Calcium Carbide as Acetylene Source in a Three ...
Calcium carbide was used in a Cu I ‐catalysed three‐component coupling with ω‐chlorinated ketones and primary amines to generate terminal 2‐alkynyl‐N‐heterocycles. The formation of an imine and the subsequent intramolecular substitution results in an active electrophilic iminium species, which can be alkynylated by in situ formed copper acetylide.